Something so disgusting you almost don't have a word for it.
Kind of like "Fucking disgusting", or "Disgusting as fuck", but really, there was no word for this sense of disgust until "Disgustifuck". Origin is unknown, but probably arose after a night of drinking and a long emotional battle to describe someone (or something) entirely repugnant.
May cause laughter.
Natty Ice is disgustifuck.
Your mom's cooch is disgustifuck.
That brodawg over there is disgustifuck.
STDs are disgustifuck.
Nazis are disgustifuck.
Your keyboard is disgustifuck.