Top Definition
Someone who is very sneaky. A devious amoeba has the ability to cause trouble without making his/her involvement known.
Person 1: "Did you hear about Andrea and Mikey?"
Person 2: "Yeah. I can't believe they broke up."
Person 1: "Something seems fishy. I think there might be a devious amoeba involved here."
by Fire D37 March 26, 2012

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