look up any word, like eiffel tower:
 
8.
When your crabs have herpes.
Oh man that dude has a horrid case of derpies.
by LIONwho March 28, 2011
 
1.
Awkward or embarrassing, especially pertaining to a person.
"Man, that guy is so awkward!"
"Yeah, he's really derpy."
by SiriusLG January 20, 2010
 
2.
adjective

accident prone; perhaps so much so that it makes one look foolish
I've been feeling pretty derpy today. Everything I touch seems to fall apart, and I cannot seem to do anything right.
by Count Schlick February 29, 2012
 
3.
Clumsy or uncoordinated; prone to cause accidents likely due to some, often humourous, mental lapse.
Ugh, I feel so derpy today. I just filled the coffee maker with pencil shavings and tried to write something down with a coffee bean.
by Count Hieronymus Schlick March 21, 2012
 
4.
Not "all there in the head"; possibly lacking intelligence or common sense. The wall-eyed background character in "My Little Pony: Friendship is Magic", Derpy Hooves, is named after this.
Hey, look at that guy sticking his aluminum foil-wrapped dick into an electrical outlet. That's derpy if I've ever seen it.

Derpy is best pony.
by Satoshiji December 31, 2011
 
5.
A disease (perhaps contagious) symptomized by using continuous "derp" actions.
"Man, I think Micheal has derpies."
"I know a few people who certainly have derpies."
by Lsh14 April 27, 2010
 
6.
(noun) 1. the unfortunate condition of permanent ugliness whose contorted nature is often misconstrued with the common phenomena of "herp-derping"
2. a title for someone who is often seen "herp-derping," whether in photographs or in real life
3. a good way to troll, or fool, others into admitting to embarrassing and most likely untrue diseases
1. Jake: "Dude, what's up with Todd's face?"
John: "I don't know man, he looks like he's herp-derping."
Todd: "Herrrrrrrrp, I have derpies."

2. Sam: "You ever notice how Todd is always derping in pictures?"
Chris: "Yeah, it's weird, I wonder if he has derpies."
Todd: "Herrrrrrrp, I have derpies."
Sam: "You don't say...."

3. Troll: "Herp, I have derpies."
Victim: "Oh yeah? Well, derp, I have herpies."
Crowd: "Booh!" "Get off the stage!"
Victim: "FFFFFFFFFFFUUUUUUUUUUUU...!"
by githeroter December 02, 2012
 
7.
A highly contagious disease originating from John Lane.
This disease is spread through acts of sheer stupidity, and there is no known cure.
Dammit, John touched me funny style and now I have da derpies
by RamstainAU September 26, 2010