look up any word, like ebola-head:
a disease you get from derping too much. very hard to get rid of, in some serious cases it's permanent. *cough* Michael! *cough*
Guy 1: "Maynee, I just came back from the doctor and I tested positive for derpes." Guy 2: "That's derpin' derped up."
by eerisedsaysshutupkevin January 13, 2010