Top Definition
Colfax Avenue is a major road that runs through the Denver metropolitan area. East Colfax is known for it's large number of low-price prostitution. Many of these prostitutes are known to have and transmit various venereal diseases and other ailments including crabs. The term Denver Crab refers to the uncleanliness of these prostitutes in Denver.
That blonde prostitute is sexy but she has Denver Crabs.
by nalpakj April 09, 2014

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