To foresaken one's manhood.
When a suppository is inserted in to a man's rectum and/or when a prisoner drops the soap.
Guy 1: Dude, watch out for the stomach flu. I heard some dude had to go to Urgent care and totally got demanalized. He's been curled up in a ball sucking his thumb for the past 3 days.
Guy 2: Damn...we should go buy him a hooker.