a university located in Chicago, Illinois.
DePaul University wants the prestige of the University of Chicago and the athletics of Northwestern. Instead, it's stuck with the prestige of UIC and the athletics of Loyola.
by Luke Massey July 02, 2006
Top Definition
Best university in Chicago and the World. Largest Catholic Universtiy in the country. In the heart of Lincoln Park, IL with the hottest honeys. Home of the DePaul Blue Demons.Chicago Joel Gray
DePaul Universtiy is the shit.
by Etown February 20, 2005

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