The act of.. metaphorically speaking.. ruining someone's significant other sexually.
Al, I totally Derezzed Erin the other night.. Metaphorically speaking of course..
by Magikarpkarp January 28, 2011
1 more definition
To dissolve into pixels.
Dude, that antivirus 2008 junk just de-rezzed my registry
by Emmurity June 21, 2009