Top Definition
a drink spiked with roofies and viagra used by the DUFF(designated ugly fat friend) in order to get laid.
"dude dont drink that its a DUFF cocktail." "i woke up with a headace and a raging boner next to a WHALE, It must have been the Duff Cocktail."
by [THE]fixer5588 March 15, 2010

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