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2. DUF
Designated Ugly Friend - the one obligatory fat chick in every group of hot chicks. see running interference
Damn, all those chicks are hot except for that one. Bailey's gonna take the duff home tonight.
by AspiringdeitY Aug 5, 2003 add a video
1. Duf
An acronym for Designated Ugly Friend. Every hot girl has a DUF simply to make her look that much hotter. This strategy also works for average looking girls.
Hey Bill, here comes Mary and her DUF. I call Mary!
by Ryan Jun 17, 2004 add a video
3. duf
designated ugly friend
"Dude that chicks UGLY!"

"Yes, she's the duf in the group."
4. duf
short for dueche fag
you shouldn't have done that you duf
by Jacob Smith Feb 5, 2004 add a video
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