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1.
short for "Downtown LA" or "Downtown Los Angeles"
Girl: Are you in Pasadena yet?
Guy: No I'm still in DTLA, it'll be about 4 more hours.
by zooeyville April 07, 2010
 
2.
I short form for Down To Lick Anus
Hey girl i sure hope your DTLA, or else im gonna go wack on yo ass
by fishy boy August 05, 2009