Top Definition
The delirious state one experiences due to a lack of sleep. This state is often accompanied by hilarity and/or disorientation. Drugs and alcohol can increase this effect. It is preferable to get d'ed up with others.
Last night I thought that shit was so funny, but I was probably just d'ed up after that GoldenEye 64 tournament.

I pulled an all nighter studying and had to take the test d'ed up.
by LukeLambert November 24, 2008

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