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1.
D it up is most commonly understood as playing very good defense.
"Come on fellas, if we hold them here we'll win the game. It's time to D it up!"
by Casey Wells January 07, 2006
 
2.
v. int.
To defecate.
see bust a dook, pinch a loaf
Man, that Chinese food really did a number on me. I gotta go D it up.
He was in the bathroom D-in' it up for like thirty minutes. Must've been a big payload.
by TriviaFox October 30, 2005