Top Definition
Any woman who has had way too many botox injections. Resulting in a face that does not move, as well as eye brows that are permanently arched.
The cast of Desperate Housewives. Each of them resembles an evil witch with skin that is way too tight on their faces. Hence making them become a Cruella de Botox.
by Shaun Martin May 30, 2009
5 Words related to Cruella de Botox

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