Crusty and Ankles being compounded into one word.

Somebody with a unusual amount of crust on their ankles.

Crankles: unusually skinny, bony ankles, which in comination with other observable traits, may indicate habitual use of methampetamine, also known as crank. A "crank skank", for example, would likely have crankles. Derived from the term "cankles" - its opposite.

The condition which usually afflicts large ladies where the ankle and calf are nearly the same diameter

When you're cranky, and grumpy, and are just flat out pissy.