Crankles: unusually skinny, bony ankles, which in comination with other observable traits, may indicate habitual use of methampetamine, also known as crank. A "crank skank", for example, would likely have crankles. Derived from the term "cankles" - its opposite.
"Check out the crankles on that ho!; bet she'll fuck me for this fuckin' phat rail!"