Top Definition
College Girl Syndrome is the event in which your significant other through high school eventually goes to college and becomes a whore. This usually encompasses most women due to the low morals of todays society. In most cases it begins when you and the love of your life go to different schools, and then you find out she's being gang banged by the local rugby team or some shit. I feel as though the sudden influx of dick as the leading cause. It has had a proven success rate of around 85% thus far.
John decided to go to Michigan. Mary decided to go to Michigan state. One night at a party, Mary got college girl syndrome and worried about not getting enough penis. She eventually broke up with john to become common street trash
by T-bagnus November 15, 2008

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