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1.
The act of constantly backing away from enemies after killing them in a first person shooter, thinking they have the Call of Duty 4 and or Call of Duty World at War perk, Martyrdom enabled. This paranoia of live grenades being dropped with every kill carries into other first person shooters, like Halo, even though they do NOT have Martyrdom.
"Ive played too much Call of Duty 4 and Call of Duty World at War that I got CoD Syndrome. So now when i try to play Halo, i think everybody has martyrdom, so i back away from them after i get the kill!"
by Big Treece November 25, 2008
 
2.
When a guy plays Call of Duty so much he ends up lacking social skills, and eventually dies a virgin.
guy 1: man my girlfriend dumped me last night
guy 2: why?
guy 1: she says i never pay enough attention to her cos i'm always on cod
guy 2: classic cod syndrome mate.
by karmaisabitch42 November 24, 2010
 
3.
The act of not showing up to a pre-planned event due to the playing of Call Of Duty or the anual release of a newer version of Call Of Duty/the release of a new Map Pack.
Kid: "Mum, I'm feeling sick today, can I have a day off school?"

Mum: "No way, I saw the commercials saying that roday is the release of the new Call Of Duty, you are going to school today and I'm gonna make you wait until Christmas to get it if you try to pull CoD Syndrome off on me again"
by Goldenhawk789 November 07, 2011
 
4.
The act of checking windows and around corners for snipers, campers and I.E.Ds in everyday life.
A: I just checked all the rooms in my house for campers.

B: I think you may have COD syndrome.
by spamlurker November 28, 2013