Top Definition
The disease of being so good looking and charming, Much like George Clooney that women actually assume you are only out to have sex with them. Thus, limiting the number of women you actually get to have sex with.
Sufferers of Clooney Syndrome include:
George Clooney
Matt Lauer
Winston Spivey
Johnny Depp
by Spivs September 14, 2008
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