Top Definition
Noun:

A mental affliction characterized by a self-centered and condescending state of mind produced upon moving to a major city from another town. Those with city syndrome think their city and its inhabitants are better than other places and their populations Thus, they rarely travel and look down on other areas/people.

Particularly present in NYC, this disease is highly resistant to treatment because sufferers rarely acknowledge their pathology.
Friend: (just moved to nyc from nj): I just can't go back to the suburbs anymore. I just can't do it, its way too boring.

Me: Fuck you, you arrogant bastard! You got City Syndrome! Since you moved to NYC from Jersey you think you're better than everyone else. You're not you pompous asshole!
by Limit531 November 25, 2009

The Urban Dictionary Mug

Lotsa space for your liquids.

Buy the mug

The Urban Dictionary Mug

Lotsa space for your liquids.

Buy the mug

The Urban Dictionary Mug

Your favorite word on a white mug.

Create a mug

The Urban Dictionary Mug

One side has the word, one side has the definition. Microwave and dishwasher safe. Lotsa space for your liquids.

Buy the mug

The Urban Dictionary T-Shirt

Soft and offensive. Just like you.

Buy the t-shirt

The Urban Dictionary T-Shirt

Smooth, soft, slim fit American Apparel shirt. Custom printed. 100% fine jersey cotton, except for heather grey (90% cotton).

Buy the t-shirt