Top Definition
The sickness that one experiences after ingesting the 5.99 CiCi's Pizza buffet where one cannot even make it out of the building before shitting on ones self.
Wayne: "Hey man lets go to CiCi's I have a Groupon!"
Corey: "Nah Son, fuck that! Last time CiCi's Syndrome hit me so hard with explosive diarrhea I thought I had macaroni pizza running down my leg!"
by FMSL August 06, 2011

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