A situation when someone physically appears to be older than s/he really is. For example, Chelsea Handler appears to be at least 44, but in reality, she's only 34.
X: Man, the past 10 yrs since graduation have been rough on Kate.
Y: Yeah, considering we are only 28 and she looks 40. Classic case of Chelsea Handler Syndrome if I've ever seen it!
by Pippenstock October 9, 2009
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Also known as CHS

A condition in which you've watched so much 'Chelsea Lately' or 'The Chelsea Handler Show' that you've come to talk, look, and move your body like her. You say things like 'shadoobie', 'pikachu', and 'little nugget', all while trashing Britney Spears. When you say things that you got from Chelsea, some people (recognizing your reference) will say "OKAY, Chelsea Handler" But as an addict, you find it complimenting.
Girl - "HELLO. I'm Kari Mackenzie, watch as I go DEEEEEEEP inside my halloween candy."
Sister - "OKAY, Chelsea Handler"
Girl - "Not my fault, I have Chelsea Handler Syndrome"
by Kari Mackenzie February 7, 2008
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