It creates a conflicting feeling in the body that most users love and become addicted to quickly.
The reference is attributed to a college fraternity (Theta Xi) from Edinboro University in Erie, PA. This became in the 1990's their "Offical" high of choice.
Matt: Because you always fucking ask them to get together with Cher and give you a cheeseburger!
Sarah: What's wrong my hansome man?
Marty: I don't feel so good...my stomach aches for something delicious but I don't know what
Sarah: I know! How about a CHEESEBURGER!!