Inexplicably, Charlie Sheen (the drug) does not show up on drug tests.
May also refer to a large joint packed with a wide assortment of drugs, including but not limited to: marijuana, opium, Ecstasy, heroin, cocaine, amphetamines, etc. A close relative to the Jeffrey.
"I have one speed. I have one gear. Go!" - Charlie Sheen, under the influence of Charlie Sheen
Oh, also star of one of the highest rated tv shows, Two and a Half Men, and he made some halfway decent movies in the 80's.
Henry: Yeah man, I still don't remember what happened! That's what I get for pulling off a Charlie Sheen...
2. Already late for work, she jumped in the shower, washed away the charlie sheen, and got dressed.