Top Definition
The instantaneous prairie dog effect that the first drag of a cigarette mixed with the first sip of a coffee creates when one first wakes up.
The origin of the California Enema stems from the lifestyle of those living in California who choose to survive on nothing but coffee & cigarettes.
"What a relaxing morning, and a smoke. OMG the california enema effect is taking over" (and you run to the toilet).
by Tashi & Mishi September 19, 2008
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