1.When somebody is Bitching at you for no good reason or nagging at you to do something you don't want to do.
Shit Bitch, quit Busting my Balls about me being out all night with my friends.
by Mojo Maniac July 10, 2008
An exclamation used, when the user is pissed off at a character in a Video Game.
"You're busting my balls Mario!"
by Bik Valbordo November 21, 2007