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1.
To pop a cherry; to lose/take one's virginity.

To break the hymen.
"Yo have you and your girl done it yet?"
"No but I'm gonna bust a hyme tonight."
by yopeacenlove September 08, 2009
 
2.
The coolest name that you can call your kid. Mixed with hymen and busta rhymes' name. It literally means someone that has sex with a lot of virgins.
I have a lot of sex with virgins, hence my first childs name is gonna be busta hymes.
by $mokin J.O.E September 28, 2007