Top definition
The act of a guy going up to a girl from behind, grabbing her crotch, and starting to dance/grind with her at a party or club.

Origin of Name: Brandeis University, a university whose men are alleged to be physically and socially awkward and inept with women.
JAP #1: Oh my g-d! That guy just gave me a Brandeis Handshake

JAP #2: Ugh, what a dork!
by thegreatrock March 12, 2010
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