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1.
During summer vacation, Tamotsu is on break from work happens to visit a particular café. It is at this café that Tamotsu meets Pico, who works there for his grandfather. Tamotsu instantly falls for Pico, believing that Pico is a girl because of his feminine appearance. However, to his disbelief, Pico claims he actually is a guy. Undeterred, Tamotsu pursues a sexual relationship with Pico, to an extent where he even persuades Pico into wearing girl clothes. When Pico asks what is he to Tamotsu, he finds himself unable to answer...
Boku no Pico is a shotacon yaoi hentai anime.
by Satoko_Houjou May 26, 2010
 
2.
A seriously messed up anime and manga.
The anime is about a little boy who cross dresses as a girl. This perverted man finds him skinny dipping and uses his feelings against him to have sex with him
every 5 minutes.
The manga is only one chapter and the anime is three episodes.
Did you see Boku no Pico yet? -Alfred F Jones

Yeah, it was disgusting. -Me
Boku no Pico
by ArthurKirkland December 29, 2013
 
3.
Noun. Some anime you don't want to watch.
Don't watch an anime called Boku-no-Pico!!!
by eve online June 01, 2014