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1.
When a woman in on her period (aka "up on blocks"). Similar to "lockdown"
We can't have sex this weekend because my girlfriend is on blockdown.
by Anthony Gentile April 30, 2007
 
2.
When you block someone on your friends list.
Friend #1: "I'm tired of Joe posting sarcastic messages on my status updates."
Friend #2: "Girl! You need to put him on BlockDown!"
by Lolita75 January 16, 2010