Very wasted, drunk, high, or just overall messed up. Comes from the words blasted and wasted smooshed together.
"I am soooo bleested right now you don't even KNOW!"
"Did you see Tommy fall off his bike? His leg is totally bleested!"
"Horatio got totally bleested on So-Co yesterday that he walked into work, pulled down his pants, and took a dump right on the floor."