When you've had way too much hot sauce for your own good and your ass is bleeding from shitting so much. It is also so inflamed that if you were to shit just one more time you may end up in reconstructive rectum surgery.
Julie: are you ok? you've been shitting for about half an hour now, do you need an ambulance?
Damian: I ate way too many burritos last night, I swear i have a bleeding donut right now