The film follows the dhampir Blade in his continuing effort to protect humans from vampires.
1.Donnie Yen, a martial arts star who plays a member of the Bloodpack (Snowman,) was also the film's fight choreographer.
2.David S. Goyer's original idea was to use Morbius as a primary villain, but Marvel decided they wanted to retain the rights to make an entirely separate franchise out of Morbius - i.e. a Morbius film, so the story was changed slightly and Jared Nomak was created to be used as the primary villain instead.
3.The phrase "a man without fear" is used in this film. This is another Marvel comic book reference, to Daredevil.
4.Pop icon Michael Jackson was originally going to have a cameo in the "House of Pain" sequence as a "Vampire Pimp" that Nyssa encounters as she searches the upstairs hall. Jackson had to drop out due to scheduling conflicts and the part was played by a Czech actor. The sequence was ultimately cut out entirely for pacing reasons.
5.During the fight with Nomak in the church part of the House of Pain, the stain glass wind is a replica of Dr. Strange's (another Marvel character who battles the occult) medallion, the magical Eye of Agamotto.
6.When Scud is introduced, he quips; "...The Dark Knight Returns." Goyer would go on to co-write with Nolan, the Batman Trilogy.
7.Wesley Snipes: (Sun Tzu) Snipes' quoting of Sun Tzu - "Keep your friends close, and your enemies closer," follows references to the works of Sun Tzu in many other Snipes movies including Passenger 57, Rising Sun and The Art of War.