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1.
A tite ass city in southern Mississippi.
guest1: "So, where we goin for vacation? Hawaii, Cancun or Biloxi."
guest2: "Oh, Biloxi of course! It's the most happnin place"
by shoVel July 24, 2003
 
2.
When something is worse than bad. When you think, "This is worse than my worst, how do you define that?"

Refers to how horrible of a city Biloxi is, especially in reference to its proximity to New Orleans.
He made the mistake of eating the live bait, and the fishing trip just went Biloxi from there.
by Happysin March 09, 2009