When a woman has one breast larger than the other.
Amy is getting a boob job to cure her biggie smalls syndrome.
by El_Karnicero January 31, 2008
When one womans breast is larger than the other.
Yo mama got one big titty and one little titty, they call the bitch biggie smalls! - Biggie Smalls syndrome
by Chips and subs November 14, 2010