Top Definition
When a woman has one breast larger than the other.
Amy is getting a boob job to cure her biggie smalls syndrome.
by El_Karnicero January 31, 2008
1 more definition
8 Words related to Biggie Smalls Syndrome
When one womans breast is larger than the other.
Yo mama got one big titty and one little titty, they call the bitch biggie smalls! - Biggie Smalls syndrome
by Chips and subs November 14, 2010

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