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5.
That one person who you keep going back to, even though it always ends up the same- bad. Much like a lab rat and the electrified cheese.
Mike, that bastard, is my big cheese.
by G October 26, 2003
 
1.
Someone knowledgeable and/or of importance and high standing in an area or feild.
1. Stop addressing me as "Dr. Cox" in front of your patients. When they find out my actual name, they tend to page me with questions when they realize just exactly how inept you really are. Oh, and as an added safety measure, from now on, I'll only be responding to "Doc," "Doctor," "Ceasar," or "The Big Cheese;" and noooo, I'm _not_ joking.

2. My dad can get us on the moon within the hour. He's a big cheese at NASA...
by NapalmStxToKids January 07, 2006
 
2.
Person who works within 4 glass walls, mostly in charge of managing the mucky mucks.
I am the almighty big cheese. Get me my septor.
by gary b. February 09, 2004
 
3.
1. A BigCheese is the head of the gang in a given area defined as turf.

Louey drove his cadillac into chicago and asked .. "who is the BigCheese.

2. New zealands Best Desert combat BF exponent Big Cheese spelt I3igCheese Godlike omnipotent righteous mofo

3.A big peice of cheese usually gouda
1. al capone is the bigcheese around chicago

2.There is only 1 I3igCheese here comes bigcheese hide in the bunkers

3.just look in holland for bigcheese it's every friggin where
by I3igCheese October 19, 2006
 
4.
One who has perfected trolling.

Levels include

1) Big Cheese

2) Expert Cheese

3) Master Big Cheese

4) Grandmaster Cheese
Dude 1: Man shut up.
Dude 2: No. I'm the Big Cheese
by Empire Oglesby February 21, 2012
 
6.
Lots and lots and lots and lots and lots and lots of money.
John works at a Intel manufacturing center, John makes lots and lots of money. But, perhaps John has a boss; his boss makes the "Big Cheese".
by iPollesion June 18, 2008
 
7.
Sarah's mom
Big Kahuna Grace
Yeah sure, I can sleep over, let me just ask the Big Cheese if she has a problem with it.
by Pantha December 28, 2008