Zoloft, a common antidepressant medication.
I got put on big z for depression. I didn't like it much.
by Fantastic Frank Lopez September 05, 2008
Top Definition
A person who thinks they are amazing when actually they are just average and are injured easily. Also a washed-up athlete.
I wish I wasn't a Big Z but sadly it is the definition of my person.
by ShowstopperLRC24 August 10, 2010
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