Top Definition
The syndrome in which a respectable girl enrolls at a Big Ten university and subsequently becomes an absolute skeezer. This can include single girls, but is typically found in females who enter school with a boyfriend and promptly cheat on and lie to their boyfriends as a result of the Big 10 influence. Once the syndrome occurs it can never be reversed, and the girls become loose for life.
Chris:"Hey Mike, did you hear about Jim's girlfriend at Indiana University?"

Mike: "Yea, I heard that she hooked up with his friend the first week she got to school."

Chris: "Big Ten Syndrome strikes again!"
by Hate Me Some Big Ten June 27, 2009
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