Top Definition
An erythema of the buttocks and upper inner thighs that resembles the red bottom of a baboon, commonly the result of systemic allergic contact dermatitis, or prolonged, rough, doggy-style banging.
1) My Baboon Syndrome was a result of my body's adverse reaction to the injection of ampicillin.

2) I pounded that bitch so hard, she gunna have Baboon Syndrome fo a week!
by HardenThicke December 03, 2009

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