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1.
1.Beign able to make large conclusions with only minisclue observations.

2. Clever, quick, cunning or ingenious.
1. Whilst watching paint dry, he said "have you noticed how there are exactally 322 bricks in this wall?"

2. He was so astute, that his resposes were 98% right everytime, which based on his school's standards was extreamly high, because they are all idiots.
by Mtbeaver November 28, 2006
 
2.
Crafty.
Architecture for the astute.
by LarstaiT November 07, 2003
 
3.
when someone is all high and lofty;
stuck up so far that their ass can't toot
that prof is sooo astute
by vincent March 17, 2004