(2) A human being, usually male, subjectively deemed to exemplify traits of the anatomic equivalent, usually due to obvious character flaws that cause emotional distress in others, or unprovoked aggressive behavior.
(3) The male equivalent of a "bitch," when "bitch" describes a woman displaying unwarranted aggressive behavior.
"Due to the relatively weak structure of the asshole's surrounding tissues in comparison to the vagina, HIV is sometimes thought erroneously to be more contagious via anal sex."
(2) "You're such an asshole for telling that old lady to fuck herself."
"My ex-boyfriend is such an asshole, calling me 10 times a day."
(3) ::After nearly getting in a barfight:: "Let's get out of here, you don't have to deal with these assholes."