Actually a combination of "Are you shitting me?" and "Are you serious?" Often used to make the expression of awe more intense, but usually it makes you look uneducated.
by Oh shit. April 21, 2009
A phrase that comes from the mixture of the emphatic expressions "no shit!" and "are you serious?" It is normally used in response to some surprising or shocking news or information. When said fast is indistinguishable from saying "are you serious?"
by perthguy April 14, 2009