Term used frequently with men, usually at parties, clubs, etc. To "hit that" means to make move on, get her to get in his pants, etc.
Guyy 1: Oh, look at that hott chick!
Guyy 2: Nice! Are you gonna hit that?
Guyy 1: OH, I'm gonna hit that up!
Guyy 2: Get her in your pants man, alright!
by Gabbie<333 February 11, 2010

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