Top Definition
When one plays soo many hours a day of video games their voice sounds like that of a dying cat. If diagnosed with APS your symptoms include no friends outside xbox live, creaming ones pants when you are bumpped by a girl, and no girls will talk to you because you sound and dress like a faggot.
"Well the orange box is from more inferior than you yourself." one with Anti-poon Syndrome would quote the orange box or bioshock
by Gooch Gore April 23, 2008

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