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A very harsh but humorous insult used on that person who is ruining the overall vibe of a situation and everyone wants to leave.

Similar to The Anti-Christ, but it is The Anti-Sice.
Person 1: "Hey DUDES what's happenin' over yonder?!?!"
Person 2: "Fuck off, you are The Anti-Sice."
by Frubens October 01, 2012