Top Definition
When a boy is hung over a girl
Man, I wish Johnny would ask me out." "Don't count on it, he's suffering from the Alyssa Effect.
by imreallyannoyedwiththis December 15, 2010
1 more definition
the effect of being annoyed, pestered or just plain pissed off by someone who constantly brings up high school stories or talks about their high school friends. rooted in college dorms where one person clings on to their old life instead of meeting new people.
You wanna go out to a party with the girls in 421 tonight?

No way man, they got the Alyssa effect goin on in there, Mary just won't shut up about her friends at home.
by they call me tater salad... October 21, 2010

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