Make sure that what you are doing and striving for is going to be worth any sacrifices you will have to make along the way. If it's a relationship, job, anything in life.
If you love someone more than life itself and will do anything to have her and shes perfect for you, yet you have to move far away and start a new life, the juice is worth the squeeze.
Or if you want to become a lawyer but it costs 100's of thousands in debt and years of studying and when you graduate you have to move to alaska but your starting salary is 400K a year, the juice was worth the squeeze. Always know if the juice is worth the squeeze.