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1.
If you don't like the human race because humans are killing eatch other, destryoing the environment, polluting the seas, wiping out trees and animal species and overpopulating the planet - then you are suffering from the Agent Smith Syndrome.

Agent Smith (Matrix Trilogy) has started the Agent Smith Syndrome. Agent Smith hated seeing humans destroying the world they are living in. Smith hated seeing humans killing eatch other. Smith didn't understand why humans have to define their existence through misery and suffering.
Someone who suffers from Agent Smith Syndrome often says/thinks: "I'm not antisocial. I just don't like humans"

Agent Smith started the Agent Smith Syndrome: "I'd like to share a revelation during my time here. It came to me when I tried to classify your species. I realized that you're not actually mammals. Every mammal on this planet instinctively develops a natural equilibrium with the surrounding environment but you humans do not. You move to an area and you multiply and multiply until every natural resource is consumed. The only way you can survive is to spread to another area. There is another organism on this planet that follows the same pattern. Do you know what it is? A virus." (quote: 'Matrix')
by TerranZ June 28, 2007
 
2.
A phenomenon occurring in video-games, typically open-world sand-box titles set in urban environments, where otherwise harmless pedestrians suddenly appear to transform into the game's principal antagonist as if in the Matrix.
Assassin's Creed is a textbook example of Agent Smith Syndrome, wherein stealth-murdering some annoying leper in a marketplace crowded with civilians suddenly leads to dozens of guards popping out of nowhere trying to chop off my limbs as if this were the Matrix and they're all Agent Smith.
by Al-toid July 27, 2009