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2.
1. An alcoholic cocktail that will make you say 'Adios' to being sober, and 'see you later' to your liver pretty quick. You might just fuck a mother in the process, or call someone this if they're a total d-bag. The recipe is as follows:

1/2 oz vodka
1/2 oz rum
1/2 oz tequila
1/2 oz gin
1/2 oz Blue Curacao liqueur
2 oz sweet and sour mix
2 oz 7-Up® soda

2. Badass way to say 'I won, you suck.' or 'I'm genetically better than you, hence, why I win in every theoretical life situation'
1. 'Hot bartender, please make me an Adios Motherfucker. I plan on getting effing LIT tonight. :-)'

2. 'Oh, you want to beat me at beer pong? Adios motherfucker. Prepare to lose. :-)'
by inBlueParadise August 07, 2011
 
1.
A drink containing a very large amount of alcohol. The name supposedly comes from what the bartender could say when he serves you one. Google for recipes. Sometimes abbreviated as AMF.
I think I had a couple of Adios Mother Fuckers last night but I don't remember exactly.
by G. Brandt May 05, 2006