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1.
A drink containing a very large amount of alcohol. The name supposedly comes from what the bartender could say when he serves you one. Google for recipes. Sometimes abbreviated as AMF.
I think I had a couple of Adios Mother Fuckers last night but I don't remember exactly.
by G. Brandt May 05, 2006
 
2.
1. An alcoholic cocktail that will make you say 'Adios' to being sober, and 'see you later' to your liver pretty quick. You might just fuck a mother in the process, or call someone this if they're a total d-bag. The recipe is as follows:

1/2 oz vodka
1/2 oz rum
1/2 oz tequila
1/2 oz gin
1/2 oz Blue Curacao liqueur
2 oz sweet and sour mix
2 oz 7-Up® soda

2. Badass way to say 'I won, you suck.' or 'I'm genetically better than you, hence, why I win in every theoretical life situation'
1. 'Hot bartender, please make me an Adios Motherfucker. I plan on getting effing LIT tonight. :-)'

2. 'Oh, you want to beat me at beer pong? Adios motherfucker. Prepare to lose. :-)'
by inBlueParadise August 07, 2011